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Monday, May 11, 2020 | History

4 edition of Tissue-specific estrogen action found in the catalog.

Tissue-specific estrogen action

Tissue-specific estrogen action

novel mechanisms, novel ligands, novel therapies

  • 8 Want to read
  • 29 Currently reading

Published by Springer in Berlin, New York .
Written in English

    Subjects:
  • Estrogen -- Receptors -- Congresses.,
  • Estrogen -- Mechanism of action -- Congresses.,
  • Estrogen -- Therapeutic use -- Congresses.

  • Edition Notes

    Includes bibliographical references.

    StatementK.S. KOrach, T. Wintermantel, editors.
    GenreCongresses.
    SeriesErnst Schering Foundation symposium proceedings -- 2006/1
    ContributionsKorach, Kenneth S., Wintermantel, Tim.
    Classifications
    LC ClassificationsQP572.E85 T57 2007
    The Physical Object
    Paginationxv, 181 p. :
    Number of Pages181
    ID Numbers
    Open LibraryOL21875858M
    ISBN 103540495479
    ISBN 109783540495475
    LC Control Number2007921596

    Start studying Bio Chapter 13 HW. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen (estradiol)-estrogen receptor complex. A second estrogen receptor also has been identified, and.

    Their action is mediated by interaction with classical estrogen receptors (ERs), ERα and ERβ, as well as the more recently identified G-protein coupled receptor 30/G-protein estrogen receptor 1 (GPER1), via both genomic and non-genomic mechanisms. Estrogens exert a variety of effects in both reproductive and non-reproductive tissues. With the discovery of ERα splice variants, prior assumptions concerning tissue-specific estrogen signaling need to be re-evaluated. Accordingly, we sought to determine the expression of the classical estrogen receptors and ERα splice variants across reproductive and non-reproductive tissues of male and.

    Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen -estrogen receptor complex. A second estrogen receptor also has been identified, and existence of.   Serum E2 thresholds establishing sufficiency of estrogen action in various tissues have been proposed. Clearly however, given the importance of E2 in male health, further studies, using increasingly available mass spectrometry assays, are needed to define the utility of serum E2 measurements in clinical practice.


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Tissue-specific estrogen action Download PDF EPUB FB2

Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies. Editors: Korach, Kenneth S, Wintermantel, Tim (Eds.) Free Preview. Tissue-specific estrogen action book Estrogen Action. Ernst Schering Foundation Symposium Proceedings (Book /1) Share your thoughts Complete your review.

Tell readers what you thought by rating and reviewing this book. Rate it * You Rated it *Brand: Springer Berlin Heidelberg. Thus, accumulating clinical experience on estrogen action in vivo helps to Tissue-specific estrogen action book the progress in molecular biological research.

Keywords Cardiovascular Biology Endocrinology Molecular Medicine Pharmacology Steroids cell biology cells endothelium estrogen. Tissue-Specific Estrogen Action. por. Ernst Schering Foundation Symposium Proceedings (Book /1) ¡Gracias por compartir.

Has enviado la siguiente calificación y reseña. Lo publicaremos en nuestro sitio después de haberla : Springer Berlin Heidelberg. Get this from a library. Tissue-specific estrogen action: novel mechanisms, novel ligands, novel therapies ; [Symposium Entitled. Get this from a library.

Tissue-specific estrogen action: novel mechanisms, novel ligands, novel therapies. [Kenneth S Korach; Tim Wintermantel;] -- Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was.

The model of tissue-specific estrogen action The recent results in steroid hormone research are useful to understand the concept of tissue selectivity. It has been demonstrated that the estrogen receptor is a highly regulated molecule whose transcriptional activity Cited by:   Murphy E., Korach K.S.

() Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues. In: Korach K.S., Wintermantel T. (eds) Tissue-Specific Estrogen Action.

Ernst Schering Foundation Symposium Proceedings, vol / by: 6. Tissue-Specific Regulation of Genes by Estrogen Receptors Article Literature Review in Seminars in Reproductive Medicine 30(1) January with 21 Reads How we measure 'reads'.

However, the direct target genes of estrogen and ERs remain largely unknown, as are the mechanisms of E2 action. In the future, a tissue-specific E2 or SERM might be an appropriate basis for the development of therapeutic regimens for by:   Discover Book Depository's huge selection of Kenneth S Korach books online.

Free delivery worldwide on over 20 million titles. Tissue-Specific Estrogen Action: Novel Mechanisms, Novel Ligands, Novel Therapies. Kenneth S Korach. 10 Jan Undefined. unavailable. The combination of conjugated estrogens and bazedoxifene is approved for women who suffer from moderate-to-severe hot flashes associated with menopause and also to prevent osteoporosis after menopause.

The medicine combines estrogen with bazedoxifene, an estrogen agonist/antagonist (also called a SERM). In women who were between 1 and 5 years post-menopause, use of this.

Tissue-bound estrogen in aging. and its indirect action by preventing prolactin from stimulating the formation of estrogen receptors, there are many other processes that can increase or decrease the tissue concentration of estrogen, and many of these influences change with aging.

Tissue specific effects of progesterone on progesterone. It has tissue specific action and acts as an estrogen receptor blocker in breast tissue and exhibits agonistic properties in the bone and uterus.

9 Although its use is primarily in women, in men’s health it is used off-label and acts as an estrogen antagonist in the hypothalamus and pituitary gland.

23 Because of its mechanism of action. Tissue-specific estrogenic response and molecular mechanism Article Literature Review in Toxicology Letters () March with Reads How we measure 'reads'Author: Patrick Diel.

The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland. By Karin Tamm, Marina Suhorutshenko, Miia Rõõm, Jaak Simm and Madis Metsis. Submitted: February 1st Reviewed: July 18th Published: January 11th DOI: /Cited by: 1.

Estrogen metabolism. Estrogen synthesis takes place primarily in the ovary (especially membrana granulose and luteinized granulosa cells) in premenopausal women and primarily in peripheral tissues in postmenopausal women [12, 22, 30].The aromatization of androgens into estrogens is the most important source of estrogens in the breast tissue [].Some active estrogens are also formed from Cited by:   Phytoestrogens are markedly similar in chemical structure to the mammalian estrogen, estradiol, and bind to ERs, with a preference for ERβ.

Selective ER modulators (SERMs) are ER ligands that in some tissues act like estrogens, but block estrogen action in others thus exerting tissue‐specific effects through selective : Divya Lakshmanan Mangalath, Chittalakkottu Sadasivan. Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

A characteristic that distinguishes these substances from pure ER agonists and antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in ATC code: L02BB.

The tissue-specific estrogen effect reflects the modulation of enzymatic activity in the tissues, specifically breast and uterus. This is shown schematically in Fig.

which indicates that tibolone and its metabolites in the breast actually alter the sulfokinase, sulfatase, and hydroxysteroid dehydrogenase enzyme activities in breast Author: David F.

Archer, John Christopher G. Gallagher. tissues. This goal led to the development of selective estrogen-receptor modulators (SERMs) (Levenson and Jordan, ).

The SERMs act as tissue-specific estrogen-receptor agonists in the bone, brain, cardiovascular system, vagina, and urogenital system and as estrogen-receptor antagonists in the breast.

Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ERa and ERß. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific : Vijay Paramanik.The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA).

A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density Cited by: 6.